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    Results: 1 to 20 of 21655

    1.

    Breast Milk-Associated Oxysterol Reverses Neonatal Brain Injury Through Gli2-Dependent Oligodendrogenesis

    (Submitter supplied) We identified an emerging oligodendrocyte committed subpopulation based on their gene expression that included Pdgfra, Cspg4 also known as Ng2, Olig1, Olig2.
    Organism:
    Mus musculus
    Type:
    Expression profiling by high throughput sequencing
    Platform:
    GPL13112
    2 Samples
    Download data:
    GEO (MTX, TSV)
    Series
    Accession:
    GSE121540
    ID:
    200121540
    2.

    TFAP2C signalling in human fibroblasts

    (Submitter supplied) Our work has shown that the transcription factor TFAP2C is upregulated in fibroblasts that generate an anisotrophic extracellular matrix. To determine what is acting downstream of TFAP2C we compared fibroblasts that had been mock transfected, or treated with a non-targeting siRNA control or siRNA against TFAP2C.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by high throughput sequencing
    Platform:
    GPL16791
    6 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE121536
    ID:
    200121536
    3.

    Genome-wide expression analysis of human hTert immortalized fibroblasts after downregulation of MCM2 & MCM7

    (Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by high throughput sequencing
    Platform:
    GPL16791
    12 Samples
    Download data:
    GEO
    Series
    Accession:
    GSE120768
    ID:
    200120768
    4.

    Genome-wide expression analysis of human hTert immortalized fibroblasts after donwregulation of MCM7

    (Submitter supplied) Minichromosome maintenance (MCM) proteins facilitate replication by licensing origins and unwinding the DNA double strand. Interestingly, the number of MCM hexamers greatly exceeds the number of firing origins suggesting additional roles of MCMs. Here we show a hitherto unanticipated function of MCM2 in cilia formation in human cells and zebrafish that is uncoupled from replication. Zebrafish depleted of MCM2 develop ciliopathy-phenotypes including microcephaly and aberrant heart looping due to malformed cilia. more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by high throughput sequencing
    Platform:
    GPL16791
    6 Samples
    Download data:
    GEO (XLS), SRA SRP163151
    Series
    Accession:
    GSE120767
    ID:
    200120767
    5.

    Genome-wide expression analysis of human hTert immortalized fibroblasts after downregulation of MCM2

    (Submitter supplied) Minichromosome maintenance (MCM) proteins facilitate replication by licensing origins and unwinding the DNA double strand. Interestingly, the number of MCM hexamers greatly exceeds the number of firing origins suggesting additional roles of MCMs. Here we show a hitherto unanticipated function of MCM2 in cilia formation in human cells and zebrafish that is uncoupled from replication. Zebrafish depleted of MCM2 develop ciliopathy-phenotypes including microcephaly and aberrant heart looping due to malformed cilia. more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by high throughput sequencing
    Platform:
    GPL16791
    6 Samples
    Download data:
    GEO (XLS), SRA SRP163150
    Series
    Accession:
    GSE120766
    ID:
    200120766
    6.

    Systems biology analysis of the effect and mechanism of Qi Jing Sheng Bai granule on leucopenia in mice

    (Submitter supplied) Qi-Jing-Sheng-Bai granule (QJSB) is a new developed traditional Chinese medicine (TCM) formula. In clinical, it has been used for the treatment of leucopenia. However, the therapeutic mechanism needs further solid investigation. In present study, we first tested the effect of QJSB on leucopenia mice induced by cyclophosphamide. QJSB was administered to leucopenia mice for 8 days. Our experiments showed that QJSB significantly increased the number of peripheral white blood cells, platelets and nucleated bone marrow cells. more...
    Organism:
    Mus musculus
    Type:
    Expression profiling by high throughput sequencing
    Platform:
    GPL21273
    12 Samples
    Download data:
    GEO (TXT), SRA SRP163042
    Series
    Accession:
    GSE120707
    ID:
    200120707
    7.

    Leprosyl whole blood transcriptome

    (Submitter supplied) Transcriptome profiles of the peripheral whole blood of leprosy patients with different clinical forms
    Organism:
    Homo sapiens
    Type:
    Expression profiling by high throughput sequencing
    Platform:
    GPL11154
    58 Samples
    Download data:
    GEO (CSV), SRA SRP164309
    Series
    Accession:
    GSE120913
    ID:
    200120913
    8.

    Comparison of expression profiles of APP-depleted prostate cancer cells (LNCaP)

    (Submitter supplied) This analysis determines the relevanve of APP in prostate cancer as potential novel redox-regulator in androgen-responsive and castration-refractory prostate cancer
    Organism:
    Homo sapiens
    Type:
    Expression profiling by high throughput sequencing
    Platform:
    GPL11154
    12 Samples
    Download data:
    GEO (XLSX), SRA SRP104390
    Series
    Accession:
    GSE98009
    ID:
    200098009
    9.

    Differentiation enhances Zika virus infection in neuronal brain cells

    (Submitter supplied) Zika virus (ZIKV) is an emerging, mosquito-borne pathogen associated with a widespread 2015–2016 epidemic in the Western Hemisphere and a proven cause of microcephaly and other fetal brain defects in infants born to infected mothers. ZIKV infections have been also linked to other neurological illnesses in infected adults and children, including Guillain-Barré syndrome (GBS), acute flaccid paralysis (AFP) and meningoencephalitis, but the viral pathophysiology behind those conditions remains poorly understood. more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by high throughput sequencing
    Platform:
    GPL16791
    6 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE121534
    ID:
    200121534
    10.

    RNA-seq analysis of diet-driven obesity and anti-obesity effects of Quercetin glucoside or Epigallocatechin gallate in Drosophila adults.

    (Submitter supplied) The High Fat Diet (HFD)-feeding significantly stimulated fat accumulation in Drosophila adults. Simultaneous feeding of known anti-obesity drugs that having the effect on rat and mouse, Quercetin Glycosides (QG) and Epigallocatechin gallate (EGCG) also suppressed fat accumulation in Drosophila at an equivalent concentration. Therefore, we have established a convenient model system to study on diet-induced fat accumulation and to evaluate effects of anti-obesity drugs using Drosophila. more...
    Organism:
    Drosophila melanogaster
    Type:
    Expression profiling by high throughput sequencing
    Platform:
    GPL19132
    8 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE121531
    ID:
    200121531
    11.

    Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid.

    (Submitter supplied) In comparison with exosomal mRNAs in CSF from four patients with amyotrophic lateral sclerosis, 543 genes were significantly changed, as represented by CUEDC2.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by high throughput sequencing
    Platform:
    GPL18573
    8 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE121519
    ID:
    200121519
    12.

    C. elegans stress-induced gene expression in low SAM or after histone-methytransferase RNAi

    (Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
    Organism:
    Caenorhabditis elegans
    Type:
    Expression profiling by high throughput sequencing
    Platform:
    GPL13657
    48 Samples
    Download data:
    GEO
    Series
    Accession:
    GSE121511
    ID:
    200121511
    13.

    Comparison of heat responsive gene expression after histone methyltransferase RNAi in C. elegans

    (Submitter supplied) We resport the changes in gene expression occuring after heat exposure in C. elegans with low s-adenosylmethionine, or RNAi of two H3K4 methyltransferases Using a C. elegans model of low SAM, we previously found that transcriptional responses response to a bacterial pathogen failed and these bacterial-response genes did not show normal H3K4me3 close to the transcriptional start sites, (Ding et al. 2015 Cell Metabolism). more...
    Organism:
    Caenorhabditis elegans
    Type:
    Expression profiling by high throughput sequencing
    Platform:
    GPL13657
    16 Samples
    Download data:
    GEO (XLSX)
    Series
    Accession:
    GSE121510
    ID:
    200121510
    14.

    Comparison of R24 responsive gene expression after histone methyltransferase RNAi in C. elegans

    (Submitter supplied) We resport the changes in gene expression occuring after R24 exposure in C. elegans with low s-adenosylmethionine, or RNAi of two H3K4 methyltransferases Using a C. elegans model of low SAM, we previously found that transcriptional responses response to a bacterial pathogen failed and these bacterial-response genes did not show normal H3K4me3 close to the transcriptional start sites, (Ding et al. 2015 Cell Metabolism). more...
    Organism:
    Caenorhabditis elegans
    Type:
    Expression profiling by high throughput sequencing
    Platform:
    GPL13657
    16 Samples
    Download data:
    GEO (XLSX)
    Series
    Accession:
    GSE121509
    ID:
    200121509
    15.

    Comparison of Pseudomonas responsive gene expression after histone methyltransferase RNAi in C. elegans

    (Submitter supplied) We resport the changes in gene expression occuring after Pseudomonas exposure in C. elegans with low s-adenosylmethionine, or RNAi of two H3K4 methyltransferases Using a C. elegans model of low SAM, we previously found that transcriptional responses response to a bacterial pathogen failed and these bacterial-response genes did not show normal H3K4me3 close to the transcriptional start sites, (Ding et al. more...
    Organism:
    Caenorhabditis elegans
    Type:
    Expression profiling by high throughput sequencing
    Platform:
    GPL13657
    16 Samples
    Download data:
    GEO (CSV)
    Series
    Accession:
    GSE121508
    ID:
    200121508
    16.

    Comparative study of gene expression during early vertebrate development between Xenopus laevis and Sturgeon

    (Submitter supplied) Sturgeon and Xenopus is estimated to be separate by about 400 My of evolution. We have collected data on temporal expression profile in Sturgeon in order to compare the level and timing of expression for homologous pairs of genes, commonly referred to as hetero-metry and hetero-chrony. Following up our previously published research on similar comparison between two species of Xenopus separated by estimated 50 My, we are asking whether patterns of expression and signaling cascades of two key developmental periods - gastrulation and neurulation are implemented via conserved molecular basis. more...
    Organism:
    Acipenser sturio
    Type:
    Expression profiling by high throughput sequencing
    Platform:
    GPL21053
    24 Samples
    Download data:
    GEO (FA, TXT), SRA SRP065233
    Series
    Accession:
    GSE74249
    ID:
    200074249
    17.

    RNA-Seq of osteosarcoma cell lines

    (Submitter supplied) The Alternative Lengthening of Telomeres (ALT) pathway stimulates telomere elongation and prevents cellular senescence in approximately 60% of osteosarcoma. While the precise mechanisms underlying the ALT pathway are unclear, mutations in the chromatin remodeling protein ATRX, histone chaperone DAXX, and the histone variant H3.3, correlate with ALT status. ATRX and DAXX facilitate deposition of the histone variant H3.3 within heterochromatic regions including the telomere suggesting that loss of ATRX, DAXX, and/or H3.3 lead to defects in heterochromatin maintenance at telomeres, ultimately contributing to ALT activity. more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by high throughput sequencing
    Platform:
    GPL18573
    39 Samples
    Download data:
    GEO, SRA SRP157750
    Series
    Accession:
    GSE118488
    ID:
    200118488
    18.

    Evaluating the effect of CovR phosphorylation on group A streptococcus global gene expression

    (Submitter supplied) We sought to determine how CovRS mutations varying CovR phosphorylation levels affect the gene expression profile of group A streptococcus
    Organism:
    Streptococcus sp. 'group A'
    Type:
    Expression profiling by high throughput sequencing
    Platform:
    GPL19691
    32 Samples
    Download data:
    GEO, SRA SRP165856
    Series
    Accession:
    GSE121313
    ID:
    200121313
    19.

    Single-cell RNA sequencing reveals novel markers of pituitary stem cells and hormone-producing cell-types

    (Submitter supplied) Transcription factors and signaling pathways that regulate stem cells and specialized hormone-producing cells in the pituitary gland have been the subject of intense study and have yielded a mechanistic understanding of pituitary organogenesis and disease. Yet, the regulation of stem cell proliferation and differentiation, the heterogeneity among specialized hormone-producing cells, and the role of non-endocrine cells in the gland remain important, unanswered questions. more...
    Organism:
    Mus musculus
    Type:
    Expression profiling by high throughput sequencing
    Platform:
    GPL21103
    2 Samples
    Download data:
    GEO (CSV, MTX, TSV), SRA SRP162513
    Series
    Accession:
    GSE120410
    ID:
    200120410
    20.

    Acquired HER2 mutations in ER+ metastatic breast cancer confer resistance to ER-directed therapies

    (Submitter supplied) Estrogen receptor positive (ER+) breast cancers that develop resistance to therapies that target the ER are the most common cause of breast cancer death. Beyond mutations in ER, which occur in 25-30% of patients treated with aromatase inhibitors (AIs), our understanding of clinical mechanisms of resistance to ER-directed therapies remains incomplete. We identified activating HER2 mutations in metastatic biopsies from eight patients with ER+ metastatic breast cancer who had developed resistance to ER-directed agents, including AIs, tamoxifen, and fulvestrant. more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by high throughput sequencing
    Platform:
    GPL18573
    864 Samples
    Download data:
    GEO (TXT), SRA SRP166112
    Series
    Accession:
    GSE121411
    ID:
    200121411

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