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    Results: 1 to 20 of 703250

    1.
    Full record GDS6177

    Acute alcohol consumption effect on whole blood (control group): time course

    Analysis of blood from subjects administered orange juice w/o alcohol. Blood collected at time points corresponding to collection times for the alcohol group in GDS4938. These results, together with those from GDS4938, provide insight into molecular response of blood during acute ethanol exposure.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array, transformed count, 5 individual, 2 protocol, 5 time sets
    Platform:
    GPL570
    Series:
    GSE20489
    25 Samples
    Download data:
    GEO (CEL)
    2.
    Full record GDS6176

    Caspase-1 deficiency effect on lipid-loaded intestines

    Analysis of the epithelial layer of intestine from Casp1-null, C57BL/6 males 2 hours after an oral lipid bolus. Caspase-1 activates the proinflammatory cytokines IL-1β and IL-18. These results, together with those from GDS4922, provide insight into the role of caspase-1 in lipid metabolism.
    Organism:
    Mus musculus
    Type:
    Expression profiling by array, transformed count, 2 genotype/variation, 3 tissue sets
    Platform:
    GPL11533
    Series:
    GSE32515
    18 Samples
    Download data:
    GEO (CEL)
    3.
    Full record GDS6083

    Chronic lymphocytic leukemia cells response to the neutralization of inhibitor of apoptosis proteins

    Analysis of chronic lymphocytic leukemia (CLL) cells treated with BV6, a Smac mimetic. CLL is characterized by B-lymphocyte accumulation, which is attributed to defective cell death. Inhibitor of apoptosis (IAP) proteins are highly expressed in CLL cells. Smac binds to and inhibits IAP proteins.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array, transformed count, 2 agent, 4 genotype/variation, 4 individual, 2 other, 2 time sets
    Platform:
    GPL570
    Series:
    GSE62533
    12 Samples
    Download data:
    GEO (CEL)
    DataSet
    Accession:
    GDS6083
    ID:
    6083
    4.
    Full record GDS6064

    Arthritic tarsal joints induced by collagen: time course

    Analysis of tarsal joints for up to 4 weeks following treatment with collagen to induce arthritis. Collagen induced arthritis is a model for rheumatoid arthritis. Results provide insight into the molecular events underlying the inflammation and bone remodeling that occurs in inflammatory arthritis.
    Organism:
    Mus musculus
    Type:
    Expression profiling by array, transformed count, 5 time sets
    Platform:
    GPL6246
    Series:
    GSE61140
    15 Samples
    Download data:
    GEO (CEL)
    5.
    Full record GDS5948

    Zipper-interacting protein kinase deficiency effect on coronary artery smooth muscle cells in vitro

    Analysis of cultured vascular smooth muscle cells following knockdown of zipper-interacting protein kinase (ZIPK). ZIPK is phosphorylated and activated by Rho-associated kinase 1 (ROCK1). These results, together with those from GDS5659, provide further insight into ROCK1 and ZIPK functions.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array, transformed count, 2 genotype/variation sets
    Platform:
    GPL6244
    Series:
    GSE56819
    6 Samples
    Download data:
    GEO (CEL)
    6.
    Full record GDS5914

    YAP transcriptional regulator depletion effect on endothelial cells

    Analysis of umbilical vein endothelial HUVEC cells depleted for the transcriptional regulator YAP. YAP binds to the SH3 domain of the transcriptional activator Yes. Results provide insight into the role of YAP in endothelial cell proliferation.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array, transformed count, 3 agent, 2 protocol sets
    Platform:
    GPL6244
    Series:
    GSE61989
    12 Samples
    Download data:
    GEO (CEL)
    7.
    Full record GDS5913

    SRPIN803 small molecule inhibitor of SRPK1 effect on retinal pigment epithelial cell line

    Analysis of retinal pigment epithelial ARPE-19 cells treated with SRPIN803, a small molecule inhibitor of serine-arginine protein kinase 1 SRPK1. SRPK1 inhibition prevents pathological angiogenesis. Results provide insight into the molecular mechanisms underlying the inhibitory activity of SRPIN803.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array, transformed count, 2 agent sets
    Platform:
    GPL570
    Series:
    GSE62947
    6 Samples
    Download data:
    GEO (CEL)
    DataSet
    Accession:
    GDS5913
    ID:
    5913
    8.
    Full record GDS5881

    Nebulin deficiency effect on the soleus

    Analysis of soleus muscles from 6 week old males with a conditional knockout of nebulin in their striated muscles. Nebulin is a giant filamentous protein that is coextensive with actin filaments of the skeletal muscle sarcomere. Results provide insight into the role of nebulin in adult muscles.
    Organism:
    Mus musculus
    Type:
    Expression profiling by array, count, 2 genotype/variation sets
    Platform:
    GPL6246
    Series:
    GSE70213
    12 Samples
    Download data:
    GEO (CEL)
    9.
    Full record GDS5880

    Nebulin deficiency effect on the quadriceps

    Analysis of quadriceps muscles from 6 week old males with a conditional knockout of nebulin in their striated muscles. Nebulin is a giant filamentous protein that is coextensive with actin filaments of the skeletal muscle sarcomere. Results provide insight into the role of nebulin in adult muscles.
    Organism:
    Mus musculus
    Type:
    Expression profiling by array, count, 2 genotype/variation sets
    Platform:
    GPL6246
    Series:
    GSE70213
    12 Samples
    Download data:
    GEO (CEL)
    10.
    Full record GDS5826

    Multiple myeloma cell lines with acquired resistance to chemotherapeutic agent carfilzomib

    Analysis of proteasome inhibitor carfilzomib-resistant multiple myeloma (MM) cell lines KMS-11/Cfz and KMS-34/Cfz, after 1 week of growth in the absence of carfilzomib. Results provide insight into the molecular mechanisms underlying the acquisition of proteasome inhibitor resistance in MM.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array, transformed count, 4 cell line, 2 cell type sets
    Platform:
    GPL570
    Series:
    GSE69078
    12 Samples
    Download data:
    GEO (CEL)
    11.
    Full record GDS5825

    Interleukin-1α deficiency effect on injured spinal cord

    Analysis of spinal cord segment from interleukin (IL)-1α -/- and IL-1β -/- C57BL/6 adults 24 hrs after spinal cord injury (SCI). IL-1α and IL-1β belong to a family of cytokines playing a key role in neurodegeneration. Results provide insight into the role of IL-1α in the neuropathology of SCI.
    Organism:
    Mus musculus
    Type:
    Expression profiling by array, transformed count, 3 genotype/variation sets
    Platform:
    GPL6246
    Series:
    GSE70302
    12 Samples
    Download data:
    GEO (CEL)
    DataSet
    Accession:
    GDS5825
    ID:
    5825
    12.
    Full record GDS5824

    Short-term high fat diet effect on epididymal adipose fractions: time course

    Analysis of primary adipocytes from epididymis of C57BL/6J males fed a 60% high fat diet (HFD) for up to 7 days to induce obesity. Results provide insight into the molecular mechanisms underlying insulin resistance in adipose tissues during early obesity.
    Organism:
    Mus musculus
    Type:
    Expression profiling by array, count, 2 protocol, 3 time, 2 tissue sets
    Platform:
    GPL6246
    Series:
    GSE65557
    18 Samples
    Download data:
    GEO (CEL)
    13.
    Full record GDS5817

    Interleukin 17A effect on monocyte-derived dendritic cells

    Analysis of in vitro-generated dendritic cells (DCs) cultured with interleukin 17A (IL-17A) in the absence or presence of interferon-γ. IL-17A is involved in chronic inflammatory diseases. Results provide insight into the impact of IL-17A on DCs and the role of these DCs in inflammatory disease.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array, count, 3 protocol, 2 time sets
    Platform:
    GPL570
    Series:
    GSE53163
    9 Samples
    Download data:
    GEO (CEL)
    14.
    Full record GDS5815

    Sunitinib effect on renal cancer xenograft tumors

    Analysis of Kyoto University Renal Cancer (KURC) xenograft tumor models, KURC1, KURC2, KURC3, treated with sunitinib, a small molecule inhibitor of receptor tyrosine kinases that is used to treat RC. Results provide insight into molecular mechanisms underlying acquired sunitinib resistance in RC.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array, count, 2 agent, 3 disease state, 3 individual sets
    Platform:
    GPL6244
    Series:
    GSE66346
    9 Samples
    Download data:
    GEO (CEL)
    15.
    Full record GDS5814

    Nitrosative stress effect on activator protein 1-deficient fission yeast

    Analysis of activator protein 1 (Pap1)-deficient 972h- strain exposed to the nitric oxide donor compound detaNONOate. Pap1 is required to combat nitrosative stress. Results provide insight into molecular mechanisms underlying the nitrosative stress response.
    Organism:
    Schizosaccharomyces pombe; Saccharomyces cerevisiae
    Type:
    Expression profiling by array, transformed count, 2 genotype/variation, 2 stress sets
    Platform:
    GPL2529
    Series:
    GSE50899
    8 Samples
    Download data:
    GEO (CEL)
    DataSet
    Accession:
    GDS5814
    ID:
    5814
    16.
    Full record GDS5813

    Bone morphogenetic protein 4 and forskolin effect on embryonic AGM VE-cadherin+ cells

    Analysis of vascular endothelial (VE)-cadherin+ cells isolated from aorta-gonad-mesonephros (AGM) region of E11.5 embryos then treated with bone morphogenetic protein (BMP) 4, adenylyl cyclase activator forskolin, or both. Results provide insight into the role of BMP signaling in AGM hematopoiesis.
    Organism:
    Mus musculus
    Type:
    Expression profiling by array, transformed count, 4 agent sets
    Platform:
    GPL1261
    Series:
    GSE62517
    8 Samples
    Download data:
    GEO (CEL)
    17.
    Full record GDS5812

    Staphylococcal alpha-toxin effect on airway epithelial cells

    Analysis of bronchial epithelial cell lines 16HBE14o- (Hla-susceptible) and S9 (Hla-resistant) treated with S. aureus recombinant alpha-toxin (rHla) for 2 hrs. Results provide insight into molecular mechanisms underlying cell type-specific responses of airway epithelial cells to alpha-toxin.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array, count, 2 agent, 2 cell line sets
    Platform:
    GPL6244
    Series:
    GSE65018
    8 Samples
    Download data:
    GEO (CEL)
    18.
    Full record GDS5811

    TGFβ1 effect on gingival fibroblasts pretreated with TGFβ-associated kinase 1 inhibitor 5Z-7-Oxozeanol

    Analysis of cultured gingival fibroblasts pre-treated with TGFβ-associated kinase 1 (TAK1) inhibitor (5Z)-7-Oxozeanol for 45 min prior to treatment with TGFβ1. Results provide insight into the extent to which TAK1 mediates fibroproliferative responses in gingival fibroblasts in response to TGFβ1.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array, transformed count, 2 agent, 2 protocol sets
    Platform:
    GPL6244
    Series:
    GSE65069
    8 Samples
    Download data:
    GEO (CEL)
    19.
    Full record GDS5810

    Hypoxia effect on von Hippel Lindau-overexpressing renal cell carcinoma cells

    Analysis of renal cell carcinoma (RCC) 786-O cells transfected with von Hippel Lindau (VHL)-overexpression vector and cultured under hypoxia conditions (1% O2) for 24 hours. Results provide insight into overlap and differences of VHL- and hypoxia-dependent molecular alterations in RCC.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array, transformed count, 2 protocol, 2 stress sets
    Platform:
    GPL6244
    Series:
    GSE65168
    8 Samples
    Download data:
    GEO (CEL)
    20.
    Full record GDS5809

    Anti-leukemia drug etoposide effect on ecotropic viral integration site 1-overexpressing myeloid cells

    Analysis of myeloid cell line U937 overexpressing ecotropic viral integration site 1 (EVI1) and cultured in the presence of antileukemic drug etoposide. Results provide insight into molecular mechanisms through which EVI1 confers resistance to drugs used in myeloid leukemia therapy.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array, transformed count, 2 agent, 2 protocol sets
    Platform:
    GPL11532
    Series:
    GSE66660
    8 Samples
    Download data:
    GEO (CEL)

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      Supplemental Content

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