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    Results: 1 to 20 of 254

    1.
    Full record GDS4992

    Cholestatic intestinal injury model: jejunum

    Analysis of jejunum from AJ and C57BL6J males with common bile duct ligation (CBDL). The two strains demonstrate different rates of cholestasis-related bacterial translocation and mortality. Results provide insight into molecular pathways underlying intestinal injury following cholestasis.
    Organism:
    Mus musculus
    Type:
    Expression profiling by array, transformed count, 2 protocol, 2 strain sets
    Platform:
    GPL6246
    Series:
    GSE47099
    12 Samples
    Download data:
    GEO (CEL)
    2.
    Full record GDS4930

    Fetal lung development

    Analysis of lung tissues at 53 to 154 days post conception. Results provide insight into the molecular regulation of lung development.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array, transformed count, 29 time sets
    Platform:
    GPL570
    Series:
    GSE14334
    38 Samples
    Download data:
    GEO (CEL)
    3.
    Full record GDS4223

    Simian Immunodeficiency Virus infection effect on lymph nodes of Sooty mangabeys and Rhesus macaques

    Temporal analysis of lymph nodes of SIVsmm infected Sooty mangabeys (SM) and SIVmac239 infected Rhesus macaques (RM). SIVsmm is non-pathogenic to host SM but origin of pathogens (HIV-2/SIVmac) to humans and RM. Results provide insight into the molecular basis of the differences in host responses.
    Organism:
    Cercocebus atys; Macaca mulatta
    Type:
    Expression profiling by array, count, 3 disease state, 3 infection, 2 species, 3 time sets
    Platform:
    GPL3535
    Series:
    GSE17626
    28 Samples
    Download data:
    GEO (CEL)
    4.
    Full record GDS3556

    Torcetrapib effect on adrenal carcinoma cell line

    Analysis of H295 adrenal carcinoma cells treated with torcetrapib, an anti-cholesterol drug. Adverse side effects of torcetrapib treatment include changes in blood pressure, potassium, sodium, and aldosterone. Results provide insight into the molecular basis of the off-target side effects.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array, transformed count, 3 agent sets
    Platform:
    GPL570
    Series:
    GSE15918
    9 Samples
    Download data:
    GEO (CEL)
    DataSet
    Accession:
    GDS3556
    ID:
    3556
    5.
    Full record GDS3190

    Macrophage response to lipopolysaccharide and interleukin-10 co-treatment: time course

    Analysis of interleukin-10 (IL-10)-deficient macrophages at various time points up to 30 minutes following co-stimulation with lipopolysaccharide (LPS) and IL-10. LPS elicits an inflammatory response. Results provide insight into molecular mechanisms underlying the anti-inflammatory effect of IL-10.
    Organism:
    Mus musculus
    Type:
    Expression profiling by array, count, 2 agent, 3 time sets
    Platform:
    GPL1261
    Series:
    GSE9509
    18 Samples
    Download data:
    GEO (CEL)
    DataSet
    Accession:
    GDS3190
    ID:
    3190
    6.
    Full record GDS1989

    Melanoma progression

    Analysis of tissue specimens representing benign nevus, atypical nevus, melanoma in situ, vertical growth phase (VGP) melanoma, and metastatic growth phase (MGP) melanoma. Results identify expression signatures that distinguish benign and atypical nevi and melanomas in situ from VGPs and MGPs.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array, count, 7 disease state, 4 specimen sets
    Platform:
    GPL570
    Series:
    GSE4587
    18 Samples
    Download data:
    GEO
    DataSet
    Accession:
    GDS1989
    ID:
    1989
    7.
    Full record GDS1850

    Carious pulpal tissue

    Expression profiling of core pulpal tissue from carious teeth. RNA pooled from 11 carious teeth. Results provide insight into the molecular events that occur during the progression of dental caries.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array, count, 2 disease state sets
    Platform:
    GPL96
    Series:
    GSE1629
    4 Samples
    Download data:
    GEO
    DataSet
    Accession:
    GDS1850
    ID:
    1850
    8.

    DNA Methylation Signatures of Crohn's disease Largely a Consequence of Inflammation

    (Submitter supplied) Crohn’s disease is a relapsing inflammatory disorder with a variable clinical course. While most patients present with purely an inflammatory phenotype (B1) at diagnosis, a subgroup (~20%) rapidly progresses to complicated disease manifestations that include stricturing (B2) within 5 years. DNA methylation is a key epigenetic mechanism that can regulate gene expression and thereby influence the development and progression of complex diseases. more...
    Organism:
    Homo sapiens
    Type:
    Methylation profiling by array
    Platform:
    GPL21145
    402 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE112611
    ID:
    200112611
    9.

    Emory University African American Microbiome in Pregnancy Cohort [Methylation]

    (Submitter supplied) All subjects were enrolled from Grady Memorial and Emory Midtown Hospitals. Subjects provided blood samples at two timepoints during pregnancy. Medical record abstraction was used to determine the presence of fetal intolerance of labor.
    Organism:
    Homo sapiens
    Type:
    Methylation profiling by genome tiling array
    Platform:
    GPL13534
    127 Samples
    Download data:
    GEO (IDAT)
    Series
    Accession:
    GSE107459
    ID:
    200107459
    10.

    Emory University African American Microbiome in Pregnancy Cohort [expression]

    (Submitter supplied) All subjects were enrolled from Grady Memorial and Emory Midtown Hospitals. Subjects provided blood samples at two timepoints during pregnancy. Medical record abstraction was used to determine the presence of fetal intolerance of labor.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL10558
    410 Samples
    Download data:
    GEO (IDAT)
    Series
    Accession:
    GSE107437
    ID:
    200107437
    11.

    ROP: Dumpster Diving in RNA-sequencing to find the source of 1 trillion reads across diverse adult human tissues

    (Submitter supplied) High-throughput RNA sequencing technologies provide an unprecedented opportunity to explore the individual transcriptome. Unmapped reads are a large and often overlooked output of standard RNA-seq analyses. Here, we present Read Origin Protocol (ROP), a tool for discovering the source of all reads originating from complex RNA molecules. We apply ROP to samples across 2630 individuals from 54 diverse human tissues. more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by high throughput sequencing; Other
    Platform:
    GPL11154
    37 Samples
    Download data:
    GEO (TXT), SRA SRP131083
    Series
    Accession:
    GSE109313
    ID:
    200109313
    12.

    ROP: Dumpster Diving in RNA-sequencing to find the source of 1 trillion reads across diverse adult human tissues

    (Submitter supplied) High-throughput RNA sequencing technologies provide an unprecedented opportunity to explore the individual transcriptome. Unmapped reads are a large and often overlooked output of standard RNA-seq analyses. Here, we present Read Origin Protocol (ROP), a tool for discovering the source of all reads originating from complex RNA molecules. We apply ROP to samples across 2630 individuals from 54 diverse human tissues. more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by high throughput sequencing
    Platform:
    GPL16791
    47 Samples
    Download data:
    GEO (TXT), SRA SRP131120
    Series
    Accession:
    GSE109484
    ID:
    200109484
    13.

    Mapping open chromatin in mouse nephron progenitor cells

    (Submitter supplied) To delineate the epigenomic profile of the Six2+ mouse nephron progenitor cells, we mapped open chromatin using ATAC-Seq in Six2+ cells from E16.5 mouse kidneys.
    Organism:
    Mus musculus
    Type:
    Genome binding/occupancy profiling by high throughput sequencing
    Platform:
    GPL19057
    6 Samples
    Download data:
    GEO (BW, TXT), SRA SRP127486
    Series
    Accession:
    GSE108424
    ID:
    200108424
    14.

    Transcriptional profile of mouse nephron progenitor cells

    (Submitter supplied) In developing mammalian kidney, nephron progenitor cells (NPC) give rise to all cells in mature nephrons. Expression of the transcription factor Six2 marks NPC in developing mouse kidneys. Within the Six2+ cell population, uncommitted NPC is marked by Cited1 expression. Towards the depletion of NPC in P2, most of the Cited1+ NPC is committed. Therefore, most of the Six2+ cells in kidney represents committed NPC. more...
    Organism:
    Mus musculus
    Type:
    Expression profiling by high throughput sequencing
    Platform:
    GPL19057
    11 Samples
    Download data:
    GEO (XLSX), SRA SRP093795
    Series
    Accession:
    GSE89264
    ID:
    200089264
    15.

    Mapping of transcription factor binding sites in mouse nephron progenitor cells

    (Submitter supplied) In developing mammalian kidney, nephron progenitor cells (NPC) give rise to all cells in mature nephrons. Several transcription factors, including Six2, Hoxd11, Osr1 and Wt1, are expressed in NPC and are essential for its maintenance and/or specification. In order to understand the regulatory functions of these factors, we mapped binding sites of Six2, Hoxd11 and Osr1 in NPC using a novel transgenic strategy, and of Wt1 in wild-type developing kidney.
    Organism:
    Mus musculus
    Type:
    Genome binding/occupancy profiling by high throughput sequencing
    Platforms:
    GPL13112 GPL19057
    23 Samples
    Download data:
    GEO (BW, TXT), SRA SRP093794
    Series
    Accession:
    GSE90016
    ID:
    200090016
    16.

    Exploring Six2 distal enhancer interactome in developing mouse kidney

    (Submitter supplied) The Six2 distal enhancer regulates expression of the 60 kb-downstream gene Six2, but does not regulate the Six3 gene which is 70 kb further downstream. CTCF ChIP-Seq and Hi-C data points to a chromatin domain boundary between Six2 and Six3 which may intervene interaction between Six2-DE and Six3. The irradiation-induced Brachyrrhine (Br) mutant allele was found to carry a 320 kb genomic inversion that includes Six2 and Six3, but not Six2DE. more...
    Organism:
    Mus musculus
    Type:
    Other
    Platform:
    GPL17021
    2 Samples
    Download data:
    GEO (BEDGRAPH), SRA SRP126784
    Series
    Accession:
    GSE108102
    ID:
    200108102
    17.

    Whole genome DNA methylation profile of sperm cells in mammalian species

    (Submitter supplied) DNA methylation in sperm is among the most important factors shaping evolution of the mammalian genome. By directly altering germline mutation rates, the DNA methylation system has shaped the CpG landscape of mammalian genomes, resulting in the CpG island phenomenon. Yet little is known about how this system itself has co-evolved with its substrate during mammalian evolution. We analyzed full-genome single-CpG DNA methylation profiles in sperm from human, chimp, gorilla, rhesus, mouse, rat and dog. more...
    Organism:
    Canis lupus familiaris; Gorilla gorilla; Rattus norvegicus
    Type:
    Methylation profiling by high throughput sequencing
    Platforms:
    GPL18694 GPL16540 GPL21650
    12 Samples
    Download data:
    GEO (TXT), SRA SRP072273
    Series
    Accession:
    GSE79566
    ID:
    200079566
    18.

    Human CD26high T cells elicit tumor immunity against multiple malignancies via enhanced migration and persistence

    (Submitter supplied) CD8+ T lymphocytes mediate potent immune responses against tumor, but the role of human CD4+ T cell subsets in cancer immunotherapy remains ill-defined. Herein, we exhibit that CD26 identifies three T helper subsets with distinct immunological properties in both healthy individuals and cancer patients. Although CD26neg T cells possess a regulatory phenotype, CD26int T cells are mainly naive and CD26high T cells appear terminally differentiated and exhausted. more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL16951
    19 Samples
    Download data:
    GEO (CSV)
    Series
    Accession:
    GSE106726
    ID:
    200106726
    19.

    Genome-wide RNA deep sequencing of CAL-101 or AKTi primed human T cells in comparison to traditionally expanded T cells

    (Submitter supplied) Differential expression patterns of total mRNA in traditionally expanded T cells (vehicle) compared to T cells expanded under drugs (AKT inhibitor and CAL-101)
    Organism:
    Homo sapiens
    Type:
    Expression profiling by high throughput sequencing
    Platform:
    GPL16791
    9 Samples
    Download data:
    GEO (TSV), SRA SRP112521
    Series
    Accession:
    GSE101497
    ID:
    200101497
    20.

    IDENTIFICATION OF ADULT ZEBRAFISH CONE PHOTORECEPTOR-ENRICHED GENES

    (Submitter supplied) Cone photoreceptors are specialised sensory retinal neurons responsible for photopic vision, colour perception and visual acuity. Retinal degenerative diseases are a heterogeneous group of eye diseases in which the most severe vision loss typically arises from cone photoreceptor dysfunction or degeneration. Establishing a method to purify cone photoreceptors from retinal tissue can accelerate the identification of key molecular determinants that underlie cone photoreceptor development, survival and function. more...
    Organism:
    Danio rerio
    Type:
    Expression profiling by array
    Platform:
    GPL1319
    6 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE86155
    ID:
    200086155

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