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    Results: 1 to 20 of 242

    1.
    Full record GDS4992

    Cholestatic intestinal injury model: jejunum

    Analysis of jejunum from AJ and C57BL6J males with common bile duct ligation (CBDL). The two strains demonstrate different rates of cholestasis-related bacterial translocation and mortality. Results provide insight into molecular pathways underlying intestinal injury following cholestasis.
    Organism:
    Mus musculus
    Type:
    Expression profiling by array, transformed count, 2 protocol, 2 strain sets
    Platform:
    GPL6246
    Series:
    GSE47099
    12 Samples
    Download data:
    GEO (CEL)
    2.
    Full record GDS4930

    Fetal lung development

    Analysis of lung tissues at 53 to 154 days post conception. Results provide insight into the molecular regulation of lung development.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array, transformed count, 29 time sets
    Platform:
    GPL570
    Series:
    GSE14334
    38 Samples
    Download data:
    GEO (CEL)
    3.
    Full record GDS4223

    Simian Immunodeficiency Virus infection effect on lymph nodes of Sooty mangabeys and Rhesus macaques

    Temporal analysis of lymph nodes of SIVsmm infected Sooty mangabeys (SM) and SIVmac239 infected Rhesus macaques (RM). SIVsmm is non-pathogenic to host SM but origin of pathogens (HIV-2/SIVmac) to humans and RM. Results provide insight into the molecular basis of the differences in host responses.
    Organism:
    Cercocebus atys; Macaca mulatta
    Type:
    Expression profiling by array, count, 3 disease state, 3 infection, 2 species, 3 time sets
    Platform:
    GPL3535
    Series:
    GSE17626
    28 Samples
    Download data:
    GEO (CEL)
    4.
    Full record GDS3556

    Torcetrapib effect on adrenal carcinoma cell line

    Analysis of H295 adrenal carcinoma cells treated with torcetrapib, an anti-cholesterol drug. Adverse side effects of torcetrapib treatment include changes in blood pressure, potassium, sodium, and aldosterone. Results provide insight into the molecular basis of the off-target side effects.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array, transformed count, 3 agent sets
    Platform:
    GPL570
    Series:
    GSE15918
    9 Samples
    Download data:
    GEO (CEL)
    DataSet
    Accession:
    GDS3556
    ID:
    3556
    5.
    Full record GDS3190

    Macrophage response to lipopolysaccharide and interleukin-10 co-treatment: time course

    Analysis of interleukin-10 (IL-10)-deficient macrophages at various time points up to 30 minutes following co-stimulation with lipopolysaccharide (LPS) and IL-10. LPS elicits an inflammatory response. Results provide insight into molecular mechanisms underlying the anti-inflammatory effect of IL-10.
    Organism:
    Mus musculus
    Type:
    Expression profiling by array, count, 2 agent, 3 time sets
    Platform:
    GPL1261
    Series:
    GSE9509
    18 Samples
    Download data:
    GEO (CEL)
    DataSet
    Accession:
    GDS3190
    ID:
    3190
    6.
    Full record GDS1989

    Melanoma progression

    Analysis of tissue specimens representing benign nevus, atypical nevus, melanoma in situ, vertical growth phase (VGP) melanoma, and metastatic growth phase (MGP) melanoma. Results identify expression signatures that distinguish benign and atypical nevi and melanomas in situ from VGPs and MGPs.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array, count, 7 disease state, 4 specimen sets
    Platform:
    GPL570
    Series:
    GSE4587
    18 Samples
    Download data:
    GEO
    DataSet
    Accession:
    GDS1989
    ID:
    1989
    7.
    Full record GDS1850

    Carious pulpal tissue

    Expression profiling of core pulpal tissue from carious teeth. RNA pooled from 11 carious teeth. Results provide insight into the molecular events that occur during the progression of dental caries.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array, count, 2 disease state sets
    Platform:
    GPL96
    Series:
    GSE1629
    4 Samples
    Download data:
    GEO
    DataSet
    Accession:
    GDS1850
    ID:
    1850
    8.

    Genome-wide RNA deep sequencing of CAL-101 or AKTi primed human T cells in comparison to traditionally expanded T cells

    (Submitter supplied) Differential expression patterns of total mRNA in traditionally expanded T cells (vehicle) compared to T cells expanded under drugs (AKT inhibitor and CAL-101)
    Organism:
    Homo sapiens
    Type:
    Expression profiling by high throughput sequencing
    Platform:
    GPL16791
    9 Samples
    Download data:
    GEO (TSV), SRA SRP112521
    Series
    Accession:
    GSE101497
    ID:
    200101497
    9.

    IDENTIFICATION OF ADULT ZEBRAFISH CONE PHOTORECEPTOR-ENRICHED GENES

    (Submitter supplied) Cone photoreceptors are specialised sensory retinal neurons responsible for photopic vision, colour perception and visual acuity. Retinal degenerative diseases are a heterogeneous group of eye diseases in which the most severe vision loss typically arises from cone photoreceptor dysfunction or degeneration. Establishing a method to purify cone photoreceptors from retinal tissue can accelerate the identification of key molecular determinants that underlie cone photoreceptor development, survival and function. more...
    Organism:
    Danio rerio
    Type:
    Expression profiling by array
    Platform:
    GPL1319
    6 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE86155
    ID:
    200086155
    10.

    The juvenile rhesus monkey (Macaca mulatta) testicular transcriptome and differential gene expression associated with the decision of undifferentiated spermatogonia to commit to the differentiation pathway

    (Submitter supplied) Goal: To identify the genes associated with the decision of undifferentiated spermatogonia to commit to a pathway of differentiation. Methods: testis mRNA profiles of 10 juvenile wild-type rhesus monkeys (3 vehicle-treated; 6 gonadotropin treated) were generated by deep sequencing, in triplicate and quadruplicate, using Illumina NextSeq500. The sequence reads that passed filters were analyzed at the transcript isoform level with TopHat followed by Cufflinks. more...
    Organism:
    Macaca mulatta
    Type:
    Expression profiling by high throughput sequencing
    Platform:
    GPL21120
    10 Samples
    Download data:
    GEO (BEDGRAPH, FA, GTF, TXT), SRA SRP103923
    Series
    Accession:
    GSE97786
    ID:
    200097786
    11.

    lncRNA dependencies in acute myeloid leukemia

    (Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
    Organism:
    Mus musculus; synthetic construct
    Type:
    Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing
    Platforms:
    GPL13112 GPL17769 GPL17021
    145 Samples
    Download data:
    GEO
    Series
    Accession:
    GSE90072
    ID:
    200090072
    12.

    shRNA screen identifies lncRNAs required for acute myeloid leukemia progresion

    (Submitter supplied) It is well understood how proteins regulate cell fate, both in normal development and disease. However, a substantial fraction of the genome is transcribed in a cell type- specific manner, producing long non-coding RNAs (lncRNA) rather than protein- coding transcripts. Here we systematically characterize transcriptional dynamics (both mRNA and lncRNA) during hematopoiesis and in hematological malignancies. more...
    Organism:
    synthetic construct
    Type:
    Non-coding RNA profiling by high throughput sequencing
    Platform:
    GPL17769
    81 Samples
    Download data:
    GEO (FASTA, XLS), SRA SRP093785
    Series
    Accession:
    GSE90065
    ID:
    200090065
    13.

    Comprenhensive lncRNA expression analysis through normal hematopoiesis and AML

    (Submitter supplied) It is well understood how proteins regulate cell fate, both in normal development and disease. However, a substantial fraction of the genome is transcribed in a cell type- specific manner, producing long non-coding RNAs (lncRNA) rather than protein- coding transcripts. Here we systematically characterize transcriptional dynamics (both mRNA and lncRNA) during hematopoiesis and in hematological malignancies. more...
    Organism:
    Mus musculus
    Type:
    Expression profiling by high throughput sequencing
    Platform:
    GPL17021
    22 Samples
    Download data:
    GEO (CSV, GTF), SRA SRP093792
    Series
    Accession:
    GSE90067
    ID:
    200090067
    14.

    RNAseq analysis of AML cells upon lncRNA knockdown

    (Submitter supplied) It is well understood how proteins regulate cell fate, both in normal development and disease. However, a substantial fraction of the genome is transcribed in a cell type- specific manner, producing long non-coding RNAs (lncRNA) rather than protein- coding transcripts. Here we systematically characterize transcriptional dynamics (both mRNA and lncRNA) during hematopoiesis and in hematological malignancies. more...
    Organism:
    Mus musculus
    Type:
    Expression profiling by high throughput sequencing
    Platform:
    GPL13112
    42 Samples
    Download data:
    GEO (TXT), SRA SRP093784
    Series
    Accession:
    GSE90059
    ID:
    200090059
    15.

    OXYGEN-LIMITED METABOLISM IN THE METHANOTROPH METHYLOMICROBIUM BURYATENSE 5GB1C

    (Submitter supplied) The bacteria that grow on methane aerobically (methanotrophs) support populations of non-methanotrophs in the natural environment by excreting methane-derived carbon. One group of excreted compounds are short-chain organic acids, generated in highest abundance when cultures are grown under O2-starvation. We examined this O2-starvation condition in the methanotroph Methylomicrobium buryatense 5GB1C . more...
    Organism:
    Methylomicrobium buryatense
    Type:
    Expression profiling by high throughput sequencing
    Platform:
    GPL23841
    14 Samples
    Download data:
    GEO (DAT), SRA SRP113731
    Series
    Accession:
    GSE101981
    ID:
    200101981
    16.

    A lncRNA fine tunes the dynamics of a cell state transition involving Lin28, let-7 and de novo DNA methylation

    (Submitter supplied) Execution of pluripotency requires progression from the naïve status represented by mouse embryonic stem cells (ESCs) to a state capacitated for lineage specification. This transition is coordinated at multiple levels. Non-coding RNAs may contribute to this regulatory orchestra. We identified a rodent-specific long non-coding RNA (lncRNA) linc1281, hereafter Ephemeron (Eprn), that modulates the dynamics of exit from naïve pluripotency. more...
    Organism:
    Mus musculus
    Type:
    Expression profiling by high throughput sequencing; Other
    Platforms:
    GPL21103 GPL17021
    19 Samples
    Download data:
    GEO (BED, BIGWIG, TXT), SRA SRP093994
    Series
    Accession:
    GSE90574
    ID:
    200090574
    17.

    Epigenetic resetting of human pluripotency

    (Submitter supplied) Recent attention has focussed on conversion of human pluripotent stem cells to a more naïve transcriptional and epigenetic status. Here we provide a simple method for resetting without transgenes via transient exposure to histone deacetylase inhibition. This protocol is effective across multiple embryo-derived and induced pluripotent stem cells. Reset cells can retain a normal karyotype over multiple passages. more...
    Organism:
    Homo sapiens
    Type:
    Methylation profiling by high throughput sequencing
    Platform:
    GPL11154
    11 Samples
    Download data:
    GEO (TXT), SRA SRP093764
    Series
    Accession:
    GSE90168
    ID:
    200090168
    18.

    Adult Cardiac Stem Cells are Multipotent and Robustly Myogenic: c-kit Expression is Necessary but not Sufficient for their Identification

    (Submitter supplied) Multipotent adult resident cardiac stem cells (CSCs) originally were identified by the expression of c-kit, the stem cell factor receptor. However, in the adult myocardium c-kit alone distinguish CSCs from other c-kit-expressing cardiac cells because the adult heart contains a heterogeneous mixture of c-kitpos cells, mainly composed of mast and endothelial/progenitor cells. This heterogeneity of cardiac c-kitpos cells has not been considered in recent c-kit-expressing cell fate mapping publications, which have equated the contribution of the whole heterogeneous c-kitpos population to cardiomyocyte generation in adulthood, which is minimal, to that of the CSCs, a result at odds with previous publications. more...
    Organism:
    Rattus norvegicus
    Type:
    Expression profiling by high throughput sequencing
    Platform:
    GPL18469
    15 Samples
    Download data:
    GEO (XLSX), SRA SRP100772
    Series
    Accession:
    GSE95420
    ID:
    200095420
    19.

    Microarray-based DNA methylation profiles of primary medulloblastomas

    (Submitter supplied) Identification of novel molecular subgroups Background: International consensus recognises four medulloblastoma molecular subgroups - WNT, SHH, Group 3 and Group 4 - each defined by their characteristic genome-wide transcriptomic and DNA methylomic profiles. Subgroups harbor distinct clinico-pathological and molecular features, underpin current disease sub-classification and initial subgroup-directed therapies are underway in clinical trials (i.e. more...
    Organism:
    Homo sapiens
    Type:
    Methylation profiling by genome tiling array
    Platform:
    GPL13534
    428 Samples
    Download data:
    GEO (IDAT, TXT)
    Series
    Accession:
    GSE93646
    ID:
    200093646
    20.

    MYC activation cooperates with Vhl and Ink4a/Arf loss to induce clear cell renal cell carcinoma

    (Submitter supplied) We present three mouse models of kidney cancer that recapitulate the genomic alterations found in human papillary (pRCC) and clear cell RCC (ccRCC), the most common RCC subtypes. MYC activation results in highly penetrant pRCC tumors (MYC), while MYC activation, when combined with Vhl and Cdkn2a (Ink4a/Arf) deletion (VIM), produce kidney tumors that approximate human ccRCC.
    Organism:
    Mus musculus
    Type:
    Expression profiling by high throughput sequencing
    Platform:
    GPL19057
    38 Samples
    Download data:
    GEO (TXT), SRA SRP103809
    Series
    Accession:
    GSE97654
    ID:
    200097654

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      Supplemental Content

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