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    Results: 1 to 20 of 275

    1.
    Full record GDS4992

    Cholestatic intestinal injury model: jejunum

    Analysis of jejunum from AJ and C57BL6J males with common bile duct ligation (CBDL). The two strains demonstrate different rates of cholestasis-related bacterial translocation and mortality. Results provide insight into molecular pathways underlying intestinal injury following cholestasis.
    Organism:
    Mus musculus
    Type:
    Expression profiling by array, transformed count, 2 protocol, 2 strain sets
    Platform:
    GPL6246
    Series:
    GSE47099
    12 Samples
    Download data:
    GEO (CEL)
    2.
    Full record GDS4930

    Fetal lung development

    Analysis of lung tissues at 53 to 154 days post conception. Results provide insight into the molecular regulation of lung development.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array, transformed count, 29 time sets
    Platform:
    GPL570
    Series:
    GSE14334
    38 Samples
    Download data:
    GEO (CEL)
    3.
    Full record GDS4223

    Simian Immunodeficiency Virus infection effect on lymph nodes of Sooty mangabeys and Rhesus macaques

    Temporal analysis of lymph nodes of SIVsmm infected Sooty mangabeys (SM) and SIVmac239 infected Rhesus macaques (RM). SIVsmm is non-pathogenic to host SM but origin of pathogens (HIV-2/SIVmac) to humans and RM. Results provide insight into the molecular basis of the differences in host responses.
    Organism:
    Cercocebus atys; Macaca mulatta
    Type:
    Expression profiling by array, count, 3 disease state, 3 infection, 2 species, 3 time sets
    Platform:
    GPL3535
    Series:
    GSE17626
    28 Samples
    Download data:
    GEO (CEL)
    4.
    Full record GDS3556

    Torcetrapib effect on adrenal carcinoma cell line

    Analysis of H295 adrenal carcinoma cells treated with torcetrapib, an anti-cholesterol drug. Adverse side effects of torcetrapib treatment include changes in blood pressure, potassium, sodium, and aldosterone. Results provide insight into the molecular basis of the off-target side effects.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array, transformed count, 3 agent sets
    Platform:
    GPL570
    Series:
    GSE15918
    9 Samples
    Download data:
    GEO (CEL)
    DataSet
    Accession:
    GDS3556
    ID:
    3556
    5.
    Full record GDS3190

    Macrophage response to lipopolysaccharide and interleukin-10 co-treatment: time course

    Analysis of interleukin-10 (IL-10)-deficient macrophages at various time points up to 30 minutes following co-stimulation with lipopolysaccharide (LPS) and IL-10. LPS elicits an inflammatory response. Results provide insight into molecular mechanisms underlying the anti-inflammatory effect of IL-10.
    Organism:
    Mus musculus
    Type:
    Expression profiling by array, count, 2 agent, 3 time sets
    Platform:
    GPL1261
    Series:
    GSE9509
    18 Samples
    Download data:
    GEO (CEL)
    DataSet
    Accession:
    GDS3190
    ID:
    3190
    6.
    Full record GDS1989

    Melanoma progression

    Analysis of tissue specimens representing benign nevus, atypical nevus, melanoma in situ, vertical growth phase (VGP) melanoma, and metastatic growth phase (MGP) melanoma. Results identify expression signatures that distinguish benign and atypical nevi and melanomas in situ from VGPs and MGPs.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array, count, 7 disease state, 4 specimen sets
    Platform:
    GPL570
    Series:
    GSE4587
    18 Samples
    Download data:
    GEO
    DataSet
    Accession:
    GDS1989
    ID:
    1989
    7.
    Full record GDS1850

    Carious pulpal tissue

    Expression profiling of core pulpal tissue from carious teeth. RNA pooled from 11 carious teeth. Results provide insight into the molecular events that occur during the progression of dental caries.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array, count, 2 disease state sets
    Platform:
    GPL96
    Series:
    GSE1629
    4 Samples
    Download data:
    GEO
    DataSet
    Accession:
    GDS1850
    ID:
    1850
    8.

    RNA Polymerase II read-through promotes expression of neighboring genes in SAL1-PAP-XRN retrograde signaling

    (Submitter supplied) Abstract: In plants, the molecular function(s) of the nuclear localised 5’-3’ EXORIBONUCLEASES (XRNs) are unclear, however their activity is reported to have a significant effect on gene expression and SAL1-mediated retrograde signaling. Using Parallel Analysis of RNA Ends (PARE) we document a dramatic increase in uncapped RNA substrates of the XRNs in both sal1 and xrn2xrn3 mutants. We find that a major consequence of reducing SAL1 or XRN activity is RNA Polymerase II (Pol II) 3’ read-through. more...
    Organism:
    Arabidopsis thaliana
    Type:
    Expression profiling by high throughput sequencing
    Platform:
    GPL19580
    21 Samples
    Download data:
    GEO (CSV), SRA SRP150771
    Series
    Accession:
    GSE115951
    ID:
    200115951
    9.

    Exposure to polybrominated biphenyl (PBB) associates with DNA methylation differences across the genome

    (Submitter supplied) Polybrominated biphenyl (PBB) is an endocrine-disrupting compound which was accidently added to the food supply in Michigan in the 1970’s. Highly exposed individuals and their children have numerous health problems, though the underlying mechanism behind these health problems remains unknown. Other endocrine-disrupting compounds have been linked to epigenetic differences, but no epigenetic studies have been done for PBB. more...
    Organism:
    Homo sapiens
    Type:
    Methylation profiling by genome tiling array
    Platform:
    GPL21145
    679 Samples
    Download data:
    GEO (CSV, IDAT)
    Series
    Accession:
    GSE116339
    ID:
    200116339
    10.

    Dynamic Patterns of Threat-associated Gene Expression in the Amygdala and Blood

    (Submitter supplied) Purpose: Identification the biological response to fear and stress in both brain and blood is vital for investigators performing peripheral studies of psychiatric traits. The goal of this study was to determine genes responsive to fear conditioning (FC), a well-characterized rodent model of threat-exposure, in the presence or absence of prior stress history, providing insight into the physiological processes underlying traumatic memory formation and trauma-related disorders such as PTSD. more...
    Organism:
    Mus musculus
    Type:
    Expression profiling by high throughput sequencing
    Platform:
    GPL15103
    30 Samples
    Download data:
    GEO (TXT), SRA SRP152146
    Series
    Accession:
    GSE116630
    ID:
    200116630
    11.

    UGA Folic acid supplementation in pregnant women

    (Submitter supplied) DNA samples were derived from maternal blood collected during a baseline prenatal visit and at delivery.
    Organism:
    Homo sapiens
    Type:
    Methylation profiling by genome tiling array
    Platform:
    GPL13534
    47 Samples
    Download data:
    GEO (IDAT)
    Series
    Accession:
    GSE114935
    ID:
    200114935
    12.

    DNA methylation and inflammation marker profiles associated with a history of depression.

    (Submitter supplied) Depression is a common and disabling disorder, representing a major social and economic health issue. Moreover, depression is associated with the progression of diseases with an inflammatory etiology including many inflammatory-related disorders. At the molecular level, the mechanisms by which depression might promote the onset of these diseases and associated immune-dysfunction are not well understood. more...
    Organism:
    Homo sapiens
    Type:
    Methylation profiling by genome tiling array
    Platform:
    GPL13534
    194 Samples
    Download data:
    GEO (CSV)
    Series
    Accession:
    GSE113725
    ID:
    200113725
    13.

    Identification and single cell functional characterization of an endodermally-biased pluripotent sub-state in human embryonic stem cells

    (Submitter supplied) Human embryonic stem cells (hESC) display substantial heterogeneity in gene expression, implying the existence of discrete substates within the stem cell compartment. To determine whether these substates impact fate decisions of hESC we used a GFP reporter line to investigate the properties of fractions of putative undifferentiated cells defined by their differential expression of the endoderm transcription factor, GATA6, together with the hESC surface marker, SSEA3. more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by high throughput sequencing
    Platform:
    GPL16791
    4 Samples
    Download data:
    GEO (TSV), SRA SRP140469
    Series
    Accession:
    GSE113168
    ID:
    200113168
    14.

    Timeseries of small RNA and mRNA expression during zebrafish heart regeneration

    (Submitter supplied) Adult zebrafish are capable of regenerating cardiac tissue following ventricular resection within 30 days. We profiled both small RNA and mRNA expression in uninjured (0dpa), 1, 3, 7, 14, 21 and 30 days post amputation to study biological processes orchestrate each stage of regeneration.
    Organism:
    Danio rerio
    Type:
    Expression profiling by high throughput sequencing
    Platform:
    GPL18413
    42 Samples
    Download data:
    GEO (TXT), SRA SRP124960
    Series
    Accession:
    GSE106884
    ID:
    200106884
    15.

    Gene expression analysis in PKP2mut cardiomyocytes

    (Submitter supplied) In the present study, genome-wide expression profiling was carried out to identify genes dysregulated in PKP2mut-iPSCs-derived cardiomyocytes.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL14550
    6 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE98525
    ID:
    200098525
    16.

    Genetic dissection of the α-globin super-enhancer in vivo [RNA-seq]

    (Submitter supplied) Many genes determining cell identity are regulated by clusters of Mediator-bound enhancer elements collectively referred to as super-enhancers. These super-enhancers have been proposed to manifest higher-order properties important in development and disease. Here we report a comprehensive functional dissection of one of the strongest putative super-enhancers in erythroid cells. By generating a series of mouse models, deleting each of the five regulatory elements of the α-globin super-enhancer individually and in informative combinations, we demonstrate that each constituent enhancer seems to act independently and in an additive fashion with respect to hematological phenotype, gene expression, chromatin structure and chromosome conformation, without clear evidence of synergistic or higher-order effects. more...
    Organism:
    Mus musculus
    Type:
    Expression profiling by high throughput sequencing
    Platform:
    GPL13112
    1 Sample
    Download data:
    GEO (BW), SRA SRP127404
    Series
    Accession:
    GSE108457
    ID:
    200108457
    17.

    NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence [RNA-Seq]

    (Submitter supplied) We decribe the accessible chormatin landscape in RAS-induced (RIS) and NOTCH induced senescence (NIS) using ATAC-seq. By expressing active NOTCH (N1ICD) in the context of RIS, we find that N1ICD antagonises the formation of accessible regions in RIS. By performing co-cultures, we demonstrate that cells expressing a NOTCH1 ligand, JAGGED1, can antagonise the formation of RIS specific accessible regions.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by high throughput sequencing
    Platform:
    GPL16791
    24 Samples
    Download data:
    GEO (TXT), SRA SRP139787
    Series
    Accession:
    GSE113060
    ID:
    200113060
    18.

    NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence

    (Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
    Organism:
    Homo sapiens
    Type:
    Genome binding/occupancy profiling by high throughput sequencing
    Platforms:
    GPL16791 GPL18573
    80 Samples
    Download data:
    GEO (BEDGRAPH, NARROWPEAK, TXT)
    Series
    Accession:
    GSE103590
    ID:
    200103590
    19.

    NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence [ChIP-Seq]

    (Submitter supplied) We describe the accessible chormatin landscape in RAS-induced (RIS) and NOTCH induced senescence (NIS) using ATAC-seq. By expressing active NOTCH (N1ICD) in the context of RIS, we find that N1ICD antagonizes the formation of accessible regions in RIS. By performing co-cultures, we demonstrate that cells expressing a NOTCH1 ligand, JAGGED1, can antagonize the formation of RIS specific accessible regions. more...
    Organism:
    Homo sapiens
    Type:
    Genome binding/occupancy profiling by high throughput sequencing
    Platform:
    GPL16791
    32 Samples
    Download data:
    GEO (BEDGRAPH, NARROWPEAK), SRA SRP117023
    Series
    Accession:
    GSE103589
    ID:
    200103589
    20.

    NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence [ATAC-Seq]

    (Submitter supplied) We describe the accessible chormatin landscape in RAS-induced (RIS) and NOTCH induced senescence (NIS) using ATAC-seq. By expressing active NOTCH (N1ICD) in the context of RIS, we find that N1ICD antagonizes the formation of accessible regions in RIS. By performing co-cultures, we demonstrate that cells expressing a NOTCH1 ligand, JAGGED1, can antagonize the formation of RIS specific accessible regions.
    Organism:
    Homo sapiens
    Type:
    Genome binding/occupancy profiling by high throughput sequencing
    Platform:
    GPL18573
    24 Samples
    Download data:
    GEO (BEDGRAPH, NARROWPEAK), SRA SRP117024
    Series
    Accession:
    GSE103588
    ID:
    200103588

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