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Fertil Steril. 2009 Apr;91(4 Suppl):1462-5. doi: 10.1016/j.fertnstert.2008.07.1710. Epub 2008 Sep 6.

The effect of blastomere biopsy on preimplantation mouse embryo development and global gene expression.

Author information

  • 1Center for Research on Reproduction and Women's Health, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

Abstract

The blastomere biopsy procedure does not affect preimplantation embryo development or global patterns of gene expression in a mouse model of Preimplantation Genetic Testing (PGT). However, zona breaching, which is inherent to the blastomere biopsy procedure, causes significant premature and sometimes abnormal hatching.

PMID:
18774571
PMCID:
PMC2683241
DOI:
10.1016/j.fertnstert.2008.07.1710
[PubMed - indexed for MEDLINE]
Free PMC Article
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