Format

Send to

Choose Destination
  • This is a preview / test site. Please update your PubMed URL to pubmed.gov.
See comment in PubMed Commons below
Int J Environ Res Public Health. 2009 Dec;6(12):2934-49. doi: 10.3390/ijerph6122934. Epub 2009 Nov 27.

Chronic stress and the development of early atherosclerosis: moderating effect of endothelial dysfunction and impaired arterial elasticity.

Author information

  • 1Department of Psychology, University of Helsinki, Helsinki, Finland. nadezda.chumaeva@helsinki.fi

Abstract

This study aims to explore the interactive effect of vital exhaustion (VE) and endothelial dysfunction on preclinical atherosclerosis, assessed by carotid intima-media thickness (IMT). Furthermore, interaction between VE and carotid elasticity is examined. Participants were 1,596 young healthy adults from the Cardiovascular Risk in Young Finns study. Endothelial dysfunction was measured by brachial flow-mediated dilatation (FMD), and carotid elasticity by carotid artery compliance (CAC). Significant interactions between FMD and VE, and between CAC and VE, for IMT were found in participants with the very lowest FMD and CAC. Thus, VE may be harmful if the endothelium is not working properly.

KEYWORDS:

atherosclerosis; carotid artery compliance; chronic stress; flow-mediated dilatation; intima-media thickness; vital exhaustion

PMID:
20049236
PMCID:
PMC2800324
DOI:
10.3390/ijerph6122934
[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for PubMed Central
    Loading ...
    Support Center