Send to

Choose Destination
  • This is a preview / test site. Please update your PubMed URL to
See comment in PubMed Commons below
Am J Ophthalmol. 2010 Jan;149(1):18-31. doi: 10.1016/j.ajo.2009.08.037.

Spectral-domain optical coherence tomography: a comparison of modern high-resolution retinal imaging systems.

Author information

  • 1Department of Ophthalmology & Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, Chicago, Illinois, USA.



To provide a review of commercially available spectral-domain optical coherence tomography (SD OCT) systems in clinical ophthalmology.




Review of current manufacturer information, selected articles from the literature, and the authors' clinical experience.


Because the premise of SD OCT technology is the nonproprietary mathematical formula of Fourier transformation, 9 different SD OCT systems currently are or soon will be commercially available. Also demonstrated are Cirrus en face C-scan visualization of photoreceptor attenuation resulting from acute zonal occult outer retinopathy and Spectral OCT/scanning laser ophthalmoscopy microperimetric analysis of a macular caldera lesion resulting from North Carolina macular dystrophy.


Advances in high-resolution imaging of the anterior and posterior segment have revealed new in vivo details of anatomic, physiologic, and pathologic data for the practice of ophthalmology. Compared with time-domain OCT, SD OCT tends to derive increased retinal thickness and decreased nerve fiber layer thickness measurements. This is likely because of increased depth of resolution and greater volume of data acquired with each scan. Interdevice comparison is not practical because of differences in individual segment boundary algorithms. Improvements in photoreceptor inner segment-outer segment layer visualization should aid our understanding of visual dysfunction in a variety of retinal pathologic features. As the technology develops, SD OCT will continue to provide new insights about ocular structure and disease.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center