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Int J Biol Macromol. 2014 Apr;65:229-33. doi: 10.1016/j.ijbiomac.2014.01.039. Epub 2014 Jan 24.

Anti-tumour and immunomodulatory activities of oligosaccharides isolated from Panax ginseng C.A. Meyer.

Author information

  • 1Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun 130117, China.
  • 2Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun 130117, China; Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China. Electronic address: syliu@ciac.jl.cn.

Abstract

Water-soluble ginseng oligosaccharides (WGOS) composed of D-glucose with a degree of polymerisation ranging from 2 to 14 were obtained from Panax ginseng C.A. Meyer. In this study, the anti-tumour and immunoregulatory effects of WGOS were evaluated in Hepatoma-22 (H22)-bearing mice. Treatment with WGOS inhibited tumour growth in vivo and significantly increased relative spleen and thymus weight, serum tumour necrosis factor-α level, spleen lymphocyte proliferation, natural killer cell activity, phagocytic function and nitric oxide production secreted by macrophage in H22-bearing mice. However, no direct cytotoxicity was detected. Therefore, the anti-tumour activity of WGOS may be related to their immunomodulatory effects.

KEYWORDS:

Anti-tumour; Immunomodulatory; Oligosaccharides; Panax ginseng

PMID:
24468047
DOI:
10.1016/j.ijbiomac.2014.01.039
[PubMed - indexed for MEDLINE]
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