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Adipocyte. 2017 Jul 3;6(3):217-223. doi: 10.1080/21623945.2017.1312040. Epub 2017 Mar 30.

Properties of porcine adipose-derived stem cells and their applications in preclinical models.

Author information

  • 1a Stephenson School of Biomedical Engineering, University of Oklahoma , Norman , OK , USA.
  • 2b School of Chemical, Biological & Materials Engineering, University of Oklahoma , Norman , OK , USA.

Abstract

Adipose-derived stem cells represent a reliable adult stem cell source thanks to their abundance, straightforward isolation, and broad differentiation abilities. Consequently, human adipose-derived stem cells (hASCs) have been used in vitro for several innovative cellular therapy and regenerative medicine applications. However, the translation of a novel technology from the laboratory to the clinic requires first to evaluate its safety, feasibility, and potential efficacy through preclinical studies in animals. The anatomy and physiology of pigs and humans are very similar, establishing pigs as an attractive and popular large animal model for preclinical studies. Knowledge of the properties of porcine adipose-derived stem cells (pASCs) used in preclinical studies is critical for their success. While hASCs have been extensively studied this past decade, only a handful of reports relate to pASCs. The aim of this concise review is to summarize the current findings about the isolation of pASCs, their culture, proliferation, and immunophenotype. The differentiation abilities of pASCs and their applications in porcine preclinical models will also be reported.

KEYWORDS:

adipose-derived stem cells; immunophenotype; in vivo studies; porcine cells; preclinical studies; stem cells isolation; translational medicine

PMID:
28410000
PMCID:
PMC5638383
[Available on 2018-03-30]
DOI:
10.1080/21623945.2017.1312040
[PubMed - in process]
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