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Acta Crystallogr F Struct Biol Commun. 2017 Oct 1;73(Pt 10):574-578. doi: 10.1107/S2053230X17013826. Epub 2017 Oct 2.

Crystallization via tubing microfluidics permits both in situ and ex situ X-ray diffraction.

Author information

  • 1CINaM-CNRS, Aix-Marseille Universit√©, Campus de Luminy, Case 913, 13288 Marseille CEDEX 09, France.
  • 2Institut de Recherches Servier, 125 Chemin de Ronde, 78290 Croissy-sur-Seine, France.
  • 3PROXIMA-1, Synchrotron SOLEIL, Gif-sur-Yvette, France.

Abstract

A microfluidic platform was used to address the problems of obtaining diffraction-quality crystals and crystal handling during transfer to the X-ray diffractometer. Crystallization conditions of a protein of pharmaceutical interest were optimized and X-ray data were collected both in situ and ex situ.

KEYWORDS:

crystallization; ex situ X-ray diffraction; in situ X-ray diffraction; microfluidics; optimization

PMID:
28994406
DOI:
10.1107/S2053230X17013826
[PubMed - in process]
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