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ACS Med Chem Lett. 2017 Sep 13;8(10):1054-1059. doi: 10.1021/acsmedchemlett.7b00264. eCollection 2017.

gem-Dinitroalkyl Benzenes: A Novel Class of IOP-Lowering Agents for the Treatment of Ocular Hypertension.

Author information

  • 1Dipartimento di Scienza e Tecnologia del Farmaco, Università degli Studi di Torino, Via P. Giuria 9, 10125 Turin, Italy.
  • 2Dipartimento di Neuroscienze, Area del Farmaco e Salute del Bambino (NEUROFARBA), Università di Firenze, Viale Pieraccini 6, 50139 Florence (FI), Italy.

Abstract

Primary open angle glaucoma is the second most common cause of blindness worldwide. Nitric oxide has recently received particular attention as a potential antiglaucoma agent. In this work, gem-dinitroalkyl benzenes are evaluated for their capability to act as a new class of IOP lowering agents. These derivatives have been endowed with a variety of NO-release capacities and found to relax contracted rat aorta strips in a concentration-dependent manner. They have been studied for their IOP-lowering activity in a transient ocular hypertensive rabbit model at 1% dose. The most effective IOP-lowering products were compounds 9-11 and 13, whose activity was similar to that of Molsidomine 120 min after administration. Compounds 9 and 13 were selected for evaluation using carbomer-induced glaucoma as the chronic model of IOP. They cause a significant reduction in IOP in the first 24 h, and their activity is maintained over 5 days, displaying a Molsidomine-like profile.

KEYWORDS:

gem-Dinitroalkyl benzenes; glaucoma; nitric oxide; ocular hypertension

PMID:
29057050
PMCID:
PMC5641960
[Available on 2018-10-12]
DOI:
10.1021/acsmedchemlett.7b00264
[PubMed]
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