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Neurology. 2007 Jan 30;68(5):350-5.

Frequency of and risk factors for HIV dementia in an HIV clinic in sub-Saharan Africa.

Author information

  • 1School of Medicine, McMaster University, Hamilton, Ontario, Canada. mhw9e@virginia.edu

Abstract

OBJECTIVE:

To measure the frequency and associated risk factors of HIV dementia in an HIV clinic in Kampala, Uganda.

METHODS:

We systematically sampled 78 HIV-seropositive (HIV+) patients from an ambulatory HIV clinic. Participants underwent detailed sociodemographic, medical history, functional, neurologic, and neuropsychological evaluations. One hundred HIV-negative patients were recruited to provide normative data for the neuropsychological tests. A logistic regression model was constructed to determine risk factors associated with the diagnosis of HIV dementia.

RESULTS:

Thirty-one percent (24 of 78) of the HIV+ patients had HIV dementia. Advanced age and low CD4(+) T-lymphocyte count (CD4 count) were the only variables identified as significant risk factors in the logistic regression model. Each additional 10 years of age conferred a greater than twofold risk of HIV dementia (OR 2.06, 95% CI: 1.05 to 4.07; p < 0.05). Reduced levels of CD4 count (100 cells/muL decrement) was associated with a 60% increase in the odds of having HIV dementia (OR 1.6, 95% CI: 1.04 to 2.33; p < 0.05).

CONCLUSION:

HIV dementia is common in HIV-seropositive Ugandan individuals attending an AIDS clinic. It is more frequently associated with patients of advanced age and decreased CD4 count.

[PubMed - indexed for MEDLINE]
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